THE BETAMETHASONE STUDIES
Archive Version :
I enclose extracts from medical studies .... at a brief read all
the studies are on kids and stretchability rates differ considerably
with children, at puberty and as adult --- big problem is that retraction
was only measurable in the flaccid state --- very interesting is that
no adhesions were found after this treatment leads me to wonder if
steroids applied to outer foreskin could "heat up" and dissolve the
epithelium ... the other good point on beta .05 is ... it seems there
is no known bad side effect ...
As Dewan points out, phimosis is often used as a quite general term
by doctors, --- I mean what should we make of comments like "Successful
treatment depends upon the presence of a normal, supple foreskin at
the outset," (Wright-JE)
Dewan makes an excellant definition
of phimosis (in its ring form), and does a comparison of a number of
previous studies - without actually getting his fingers messy himself
..- so it seems no-one has actually studied the effectiveness of beta05
on phimotic rings ... these studies are all very recent we could be
hopeful that Dewan`s conclusion-summaries be followed up ...
Robin
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Wright-JE
The treatment of childhood phimosis with topical steroid [see comments]
[published erratum appears in Aust N Z J Surg 1995 Sep;65(9):698],
Comment in: Aust N Z J Surg 1994 Dec;64(12):861. Comment in: Aust N
Z J Surg 1995 Jan;65(1):57-8
University of Newcastle Medical School, New South Wales, Australia.
Aust-N-Z-J-Surg. 1994 May; 64(5): 327-8
Abstract
A prospective study of the efficacy of topical steroid in the treatment
of childhood phimosis is reported. Boys referred to a paediatric surgical
practice with pathological non-retractable foreskins were treated for
at least 1 month with topical beta methasone cream. One hundred and
thirty-nine patients were treated and 111 completed the study. A satisfactory
result, defined as foreskin retractability appropriate for the boys'
age, was achieved in 80% of patients. In 10% the response was inadequate
at the end of the study period, but these boys were still under treatment
or surveillance because their parents declined circumcision. In 10%,
circumcision was performed because of failure of treatment. In six
patients this was due to balanitis xerotica obliterans (lichen sclerosis
et atrophicus) which does not respond to conservative treatment. Successful
treatment depends upon the presence of a normal, supple foreskin at
the outset, and on parental compliance.
Kikiros CS, Beasley SW, Woodward AA.
The response of phimosis to local steroid application.
Pediatr Surg Int 1993; 8: 329-32.
Local application of steroid ointment to the foreskin results in resolution
of phimosis in the majority of cases, but if the foreskin has a circumferential
white scar, it is slightly less likely to respond. Following cessation
of steroids, phimosis re-develops in a proportion of patients.
The main current surgical indication for circumcision is phimosis,
although recurrent balanitis and paraphimosis may be considered relative
indications. .... Phimosis, which is defined as constriction of the
preputial orifice so that it cannot be drawn back over the glans, ...
Thick fibrous scars of the prepuce appear to be more resilient to local
steroids, .... It is possible that the daily gentle retraction of the
foreskin to expose that part onto which the ointment is applied has
contributed to the improved retractibility, but in an earlier unpublished
study there was a significant difference between the application of
steroids and the application of a placebo (non-steroid preparation). |